3 years ago

OCT angiography fractal analysis-based quantification of macular vascular density in BRVO eyes

Vivek P. Dave, Rajeev R. Pappuru, Rushin Gindra, Abhishek Ananthakrishnan, Sankalp Modi, Mihika Trivedi, Peguda Harikumar

Publication date: Available online 30 August 2018

Source: Canadian Journal of Ophthalmology

Author(s): Vivek P. Dave, Rajeev R. Pappuru, Rushin Gindra, Abhishek Ananthakrishnan, Sankalp Modi, Mihika Trivedi, Peguda Harikumar


To compare the macular vascular density in branch retinal vein occlusion (BRVO) versus normals on optical coherence tomography angiography (OCTA) using fractal analysis and to describe the factors bearing on final visual outcomes.


This study is a retrospective observational comparative case series. Diagnosed cases of unilateral BRVO that underwent treatment and resolved were included. The other eye served as control.


OCTA images of the cases and control eyes were analyzed using fractal dimension on the MATLAB platform. Vascular density fraction was calculated for each eye for both the retinal vascular layers. Images were cleaned of artifacts before processing. Total vascular density in normals was compared with those with branch retinal vein occlusion.


116 eyes were normal and 98 had BRVO. The mean age of the normals was 56.63 ± 12.5 years and 58.41 ± 10.7 years of the BRVO group (p = 0.6). Superficial vascular density fraction was noted as 0.29 ± 0.08 (95% CI 0.27–0.31) and 0.25 ± 0.1 (95% CI 0.23–0.27) respectively (p = 0.003). Deep vascular density was noted as 0.39 ± 0.11 (95% CI 0.32–0.41) and 0.14 ± 0.09 (95% CI 0.12–0.19) (p < 0.0001). Pearson's correlation coefficient was -0.4 (p = 0.04) for the effect of age on vascularity, -0.53 (p = 0.001) for the effect of vascularity on final vision, and 0.35 (p = 0.09) for the effect of duration of symptoms on final vision.


In BRVO vascular density decreases significantly in the deeper retinal layer. Vision deficit correlates to increased age, duration of symptoms, and greater vascularity loss.

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.