3 years ago

Snapshot summary of diagnosis and management of hepatocellular adenoma subtypes

Paulette Bioulac-sage, Christine Sempoux, Nora Frulio, Brigitte Le Bail, Jean Frédéric Blanc, Claire Castain, Christophe Laurent, Hervé Trillaud, Laurence Chiche, Charles Balabaud

Publication date: Available online 10 September 2018

Source: Clinics and Research in Hepatology and Gastroenterology

Author(s): Paulette Bioulac-Sage, Christine Sempoux, Nora Frulio, Brigitte Le Bail, Jean Frédéric Blanc, Claire Castain, Christophe Laurent, Hervé Trillaud, Laurence Chiche, Charles Balabaud

Abstract

Hepatocellular adenomas (HCA) are rare benign hepatocellular tumors occurring mainly in women taking oral contraceptives with 2 major complications: severe bleeding and malignant transformation that can be avoided if nodules exceeding 5 cm are resected. This simple attitude has been challenged in the recent years with HCA in men, in young adolescent, in aged persons, and complications in hepatocellular adenomas below 5 cm. The discovery of specific mutations leading to specific phenotypes has modified the clinical spectrum of the disease. The phenotypic immune classification of HCA based on the molecular classification is being widely used in liver referral centers. The aim of this snapshot is to briefly present for each subtype the clinical, pathological, immuno-pathological criteria as well as the risk of complications and guidelines for treatment and management.

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