3 years ago

Surgical outcomes between patients with and without a cirrhotic liver undergoing laparoscopic liver resection: A meta-analysis

Chunling Wang, Zhangkan Huang, Xiaozhun Huang, Caixia Liu, Zhanzhou Lin, Xuelan Lu, Fengxiang Shi, Biao Zheng, Shuisheng Zhang, Fanyuan Wen

Publication date: Available online 10 August 2018

Source: Clinics and Research in Hepatology and Gastroenterology

Author(s): Chunling Wang, Zhangkan Huang, Xiaozhun Huang, Caixia Liu, Zhanzhou Lin, Xuelan Lu, Fengxiang Shi, Biao Zheng, Shuisheng Zhang, Fanyuan Wen


Laparoscopic surgery in patients with liver cirrhosis (CL) is considered to be challenging. Recent studies have shown that laparoscopic liver resection (LLR) is more beneficial of reduced operative stress and postoperative complications in patients with CL.


A meta-analysis was done to review the currently available published data comparing LLR for patients with CL versus those non-cirrhosis of the liver (NCL).


The electronic databases of PubMed, Wiley, Web of Science, Embase, and the Cochrane Library were searched from date of inception to January 29, 2018. Studies reporting a comparison of outcomes and methods of LLR in CL and NCL groups were included. The studies were evaluated using the modified Newcastle-Ottawa Scale.


A total of 1573 patients from six cohort studies were included in final analysis. The CL group had a slightly shorter operative time compared with the NCL group (weighted mean difference [WMD], 18.78 min shorter; 95% confidence interval [CI], −43.54–5.98; P = 0.14) and delayed hospital stay (WMD, 1.26 days longer; 95% CI, −0.05–2.56; P = 0.06). Blood loss, blood transfusion rate, mortality, and conversion rate did not differ significantly between the groups.


LLR is safe and feasible in the CL compared with the NCL groups. Our present review indicates that LLR should be considered when selecting surgery for patients with CL.

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