3 years ago

From structure to novel reactivity in frustrated Lewis pairs

Jan Paradies

Publication date: 1 February 2019

Source: Coordination Chemistry Reviews, Volume 380

Author(s): Jan Paradies

Abstract

The coexistence of a strong Lewis acid and a Lewis base in solution, the so called frustrated Lewis pair, has led to the discovery of metal-free hydrogen activation. Since then, this observation has inspired numerous chemists to develop more examples. Metal-free hydrogenation is so far the most studied application of frustrated Lewis pairs in chemistry and highly efficient methodologies for a number of substrates have been developed. However, the targeted choice of a FLP-catalyst is yet rather intricate, due to the lack of an in depth understanding of FLP-reactivity. The presented structure-reactivity-relationship for hydrogenation reactions allowed the targeted development and optimization of unprecedented reactions using FLPs as catalysts. This article provides insight into FLP-reactivity by summarizing our mechanistic and synthetic work in this field.

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