3 years ago

Negative Control of RpoS Synthesis by the sRNA ReaL in Pseudomonas aeruginosa.

Hue Thi Bach Nguyen, David Romero A., Fabian Amman, Theresa Sorger-Domenigg, Muralidhar Tata, Elisabeth Sonnleitner, Udo Bläsi
Pseudomonas aeruginosa (Pae) is an opportunistic human pathogen, able to resist host defense mechanisms and antibiotic treatment. In Pae, the master regulator of stress responses RpoS (σS) is involved in the regulation of quorum sensing and several virulence genes. Here, we report that the sRNA ReaL translationally silences rpoS mRNA, which results in a decrease of the RpoS levels. Our studies indicated that ReaL base-pairs with the Shine-Dalgarno region of rpoS mRNA. These studies are underlined by a highly similar transcription profile of a rpoS deletion mutant and a reaL over-expressing strain.

Publisher URL: http://doi.org/10.3389/fmicb.2018.02488

Open URL: https://doi.org/10.3389/fmicb.2018.02488

DOI: 10.3389/fmicb.2018.02488

Open access
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