3 years ago

Isothermal phase transformations of bovine-derived hydroxyapatite/bioactive glass: a study by design of experiments

July Andrea Rincón-lópez, Jennifer Andrea Hermann-muñoz, David Andrés Fernández-benavides, Astrid Lorena Giraldo-betancur, Juan Manuel Alvarado-orozco, Juan Muñoz-saldaña

Publication date: Available online 13 November 2018

Source: Journal of the European Ceramic Society

Author(s): July Andrea Rincón-López, Jennifer Andrea Hermann-Muñoz, David Andrés Fernández-Benavides, Astrid Lorena Giraldo-Betancur, Juan Manuel Alvarado-Orozco, Juan Muñoz-Saldaña


In this work, a systematic methodology to obtain third-generation bioceramics within the Ca2SiO4-Ca3(PO4)-NaCaPO4ternary system is proposed. The synthesis of Silicocarnotite (Ca5-x(PO4)2+x(SiO4)1-x; x ≤ 0.3) (SC) and Nagelschmidtite (Ca7-xNax(PO4)2+x(SiO4)2-x; x ≤ 2) (Nagel) single phases, from mixtures of bovine-derived HAp (BHAp) and 45S5-bioactive glass (BG) as precursors was developed using design of experiments (DoE). A combination of milling and sintering processing parameters was established by statistical analysis to optimize the microstructural and mechanical properties of BHAp/BG ceramics. The optimized sintering temperature obtained with simultaneous responses was 1220 °C. Variations in BHAp/BG ratios lead to isothermal phase transformation to single crystalline phases, where 85/15 and 70/30 vol:vol ratios transformed to SC and Nagel, respectively. Finally, the proposed methodology allows a feasible composition control depending only of BHAp/BG ratio to obtain non-stoichiometric SC and Nagel phases with potential applications in bone repair.

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.