3 years ago

Actinic keratosis and diabetes complications: A nationwide population-based study in South Korea (2009–2015)

Youngbok Lee, Jihyun Lee, Jinyoung Choi, Dongsoo Yu, Kyungdo Han, Yong-gyu Park

Publication date: Available online 29 November 2017

Source: Diabetes & Metabolism

Author(s): YoungBok Lee, JiHyun Lee, JinYoung Choi, DongSoo Yu, KyungDo Han, Yong-Gyu Park

Abstract
Aim

As the associations between actinic keratosis (AK) and diabetes complications in patients with diabetes mellitus (DM) have never been investigated, this study aimed to evaluate any such associations in patients with DM.

Methods

This retrospective cohort study analyzed clinical data for DM patients aged > 40 years who had undergone the health examination recommended by the South Korea National Health Insurance Program between 2009 and 2012 (n = 2,056,580). All of these patients were classified according to the presence of diabetic retinopathy (DR), end-stage renal disease (ESRD) and history of DVD; myocardial infarction, stroke, transient ischaemic attacks. Newly diagnosed AK was identified using claims data from baseline to the date of diagnosis or 31 December 2015, whichever came first.

Results

Of the 2,056,580 patients with DM, 6404 (0.31%) developed AK. Those patients in the DR, ESRD and CVD groups were more likely to be diagnosed with AK (P < 0.001, by log-rank test). After adjusting for age and gender, the risks for AK were significantly higher in the DR, ESRD and CVD groups: HR (95% CI): 1.29 (1.21–1.39), HR: 4.24 (3.28–5.47) and HR: 1.22 (1.13–1.31), respectively.

Conclusion

This study has revealed that the incidence of AK is higher in diabetes patients with ocular, renal and cardiovascular complications.

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.