4 years ago

Rhodium(I)-Catalyzed Tertiary Phosphine Directed C−H Arylation: Rapid Construction of Ligand Libraries

Rhodium(I)-Catalyzed Tertiary Phosphine Directed C−H Arylation: Rapid Construction of Ligand Libraries
Zhuangzhi Shi, Yue Zhao, Xiaodong Qiu, Minyan Wang
Modification of commercially available monophosphine ligands with either aryl bromides or chlorides by rhodium(I)-catalyzed, tertiary phosphine directed C−H activation is described. A series of ligand libraries containing mono- and diaryl-substituted groups, having different steric and electronic properties, were obtained in high yields. Based on the outstanding properties of their parent scaffolds, the modified ligands have been found to be powerful in organic reactions. Ligand-to-ligand: A catalytic rhodium system has been established for direct and site-selective arylation of commercially available phosphine ligands by tertiary phosphine directed C−H activation. A series of monophosphine ligand libraries containing mono- and diaryl-substituted groups, having different steric and electronic properties, were obtained in high yields.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201703354

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