3 years ago

Impacto del manejo perioperatorio en el pronóstico oncológico del cáncer de mama no metastásico. Un paradigma de futuro

Tatiana Gómez-sánchez, Francisco Javier Arroyo-fernández, Leticia Gómez-sánchez

Publication date: April–June 2018

Source: Revista de Senología y Patología Mamaria, Volume 31, Issue 2

Author(s): Tatiana Gómez-Sánchez, Francisco Javier Arroyo-Fernández, Leticia Gómez-Sánchez

Resumen
Introducción

La aparición de recidivas locales o metástasis a distancia suele ser la principal causa de muerte en el cáncer de mama.

Objetivos

Valorar y revisar la implicación de la técnica anestésica y/o la analgesia perioperatoria y postoperatoria en la aparición de recurrencias y el pronóstico del cáncer de mama.

Material y métodos

Se realiza una revisión de la literatura con el objetivo de obtener los estudios que relacionen la anestesia y la analgesia peri y postoperatoria con el pronóstico oncológico del cáncer de mama.

Resultados

Tras la búsqueda se obtuvo un total de 146 estudios, de los cuales se seleccionaron 9 para su análisis exhaustivo.

Discusión

La capacidad de las células tumorales para evadir la inmunidad del paciente es la clave del desarrollo de las metástasis. La inmunosupresión y la activación de mediadores de la inflamación durante el periodo perioperatorio pueden estar implicadas en la recurrencia de la enfermedad.

Conclusión

El uso de opiáceos, los anestésicos inhalatorios y la técnica anestésica parecen tener una influencia negativa en el pronóstico oncológico, aunque hoy en día solo existen estudios en animales o in vitro.

Abstract
Introduction

Recurrent disease or metastases are the main cause of death from breast cancer.

Objectives

To assess the influence of perioperative and postoperative anaesthetic and analgesic techniques on the appearance of recurrences and breast cancer prognosis.

Material and methods

A literature search was conducted for studies that assessed perioperative and postoperative anaesthetic technique and analgesia in relation to the oncological prognosis of breast cancer.

Results

We identified 146 studies and selected 9 studies for a full text reading.

Discussion

The ability of tumour cells to escape patient immunity is the key to the development of metastases. Patient immunosuppression and perioperative inflammatory mediators could be involved in recurrence.

Conclusion

The use of opioids, inhalational anaesthesia and the anaesthetic technique seem to have a negative influence on prognosis. However, there are currently only animal on in vitro studies on this topic.

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.