3 years ago

Zebrafish fatty acids receptor Gpr84 enhances macrophage phagocytosis

Min Wang, Xueyang Zhang, Shicui Zhang, Zhenhui Liu

Publication date: January 2019

Source: Fish & Shellfish Immunology, Volume 84

Author(s): Min Wang, Xueyang Zhang, Shicui Zhang, Zhenhui Liu


GPR84 was identified as a receptor for medium-chain fatty acids with carbon chain lengths of 9–14. It has previously been reported that lipopolysaccharide (LPS) induces significantly up-regulation of zebrafish gpr84, and zebrafish gpr84 overexpression markedly increased the LPS-stimulated production of the cytokine IL-12. Here we expanded on these studies to further investigate the roles of zebrafish Gpr84 in immune reaction. Flow cytometric assay was used to assess the effects of zebrafish Gpr84 on the phagocytosis of bacteria by macrophages. It was found that overexpression of zebrafish gpr84 significantly increased both the phagocytic ability (PA) and phagocytic index (PI) values of the macrophages engulfing the bacteria, suggesting that zebrafish Gpr84 was able to promote the phagocytosis of bacteria by the macrophages. The data proves the direct effect of Gpr84 in immune reaction.

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