Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry
5 years ago

A NHC-catalyzed 1,3-dipolar cycloaddition reaction of allyl ketones with azides: direct access to 1,4,5-trisubstituted 1,2,3-triazoles

A NHC-catalyzed 1,3-dipolar cycloaddition reaction of allyl ketones with azides: direct access to 1,4,5-trisubstituted 1,2,3-triazoles
Wenjun Li, Lili Zhang, Jian Wang, Huijun Yuan, Yang Liu, Zhantao Liu
A NHC-catalyzed 1,3-dipolar cycloaddition reaction of allyl ketones with azides has been developed. This strategy could generate 1,4,5-trisubstituted 1,2,3-triazoles in high yields and regioselectivities in the presence of a 20 mol% N-heterocyclic carbene catalyst. A broad substrate scope of this process is also presented.

Publisher URL: http://feeds.rsc.org/~r/rss/OB/~3/5QxhKvfqbbY/C7OB00906B

DOI: 2017/OB/C7OB00906B

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