Reconstruction of in vivo-like in vitro model: Enabling technologies of microfluidic systems for dynamic biochemical/mechanical stimuli
Publication date: Available online 14 November 2018
Source: Microelectronic Engineering
Author(s): Sang Min Park, Seongsu Eom, Hyeonjun Hong, Jaeseung Yoon, Seong Jin Lee, Bum Chang Kim, Hyung Woo Kim, Dong Sung Kim
In the past two decades, significant advances have been achieved for the emergence and rapid growth of in vivo-like in vitro cell culture platforms, especially organ-on-a-chip, which are inspired by the human organs with the goal to provide a new insight into fundamental biology and pharmaceutics. The basis for the reconstruction of in vivo-like in vitro model are stemmed from the advance of the microfabrication techniques and microfluidic systems to achieve physiological structural microenvironment and dynamic biochemical/mechanical stimuli. Here, we aim to highlight recent advances of enabling technologies for in vitro culture platform to simulate organ-specific microstructure or dynamic stimuli. These technologies allowed to construct physiological tissue or organ microstructures and tissue-tissue interfaces and to reproduce dynamic biochemical and mechanical microenvironments to guide functional tissue or organ formation.