3 years ago

Reconstruction of in vivo-like in vitro model: Enabling technologies of microfluidic systems for dynamic biochemical/mechanical stimuli

Sang Min Park, Seongsu Eom, Hyeonjun Hong, Jaeseung Yoon, Seong Jin Lee, Bum Chang Kim, Hyung Woo Kim, Dong Sung Kim

Publication date: Available online 14 November 2018

Source: Microelectronic Engineering

Author(s): Sang Min Park, Seongsu Eom, Hyeonjun Hong, Jaeseung Yoon, Seong Jin Lee, Bum Chang Kim, Hyung Woo Kim, Dong Sung Kim


In the past two decades, significant advances have been achieved for the emergence and rapid growth of in vivo-like in vitro cell culture platforms, especially organ-on-a-chip, which are inspired by the human organs with the goal to provide a new insight into fundamental biology and pharmaceutics. The basis for the reconstruction of in vivo-like in vitro model are stemmed from the advance of the microfabrication techniques and microfluidic systems to achieve physiological structural microenvironment and dynamic biochemical/mechanical stimuli. Here, we aim to highlight recent advances of enabling technologies for in vitro culture platform to simulate organ-specific microstructure or dynamic stimuli. These technologies allowed to construct physiological tissue or organ microstructures and tissue-tissue interfaces and to reproduce dynamic biochemical and mechanical microenvironments to guide functional tissue or organ formation.

Graphical Abstract

Unlabelled Image

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.