3 years ago

Combining culture and microbead‐based immunoassay for the early and generic detection of bacteria in platelet concentrates

Ludivine Vossier, Lionel Valera, Fanny Leon, Stéphanie Roche, Dominique Piquer, Laetitia Rubrecht, Christine Favier, Gaelle-Anne Cremer, Agnès Pouzet, Typhaine Dagland, Stéphane Rihet, Pascale Galea, Carole Farre, Romaric Bonnet, Nicole Jaffrézic-Renault, Carole Chaix, Jeannette Fareh, Chantal Fournier-Wirth

Abstract

BACKGROUND

Despite current preventive strategies, bacterial contamination of platelets is the highest residual infectious risk in transfusion. Bacteria can grow from an initial concentration of 0.03–0.3 colony‐forming units (CFUs)/mL up to 108 to 109 CFUs/mL over the product shelf life. The aim of this study was to develop a cost‐effective approach for an early, rapid, sensitive, and generic detection of bacteria in platelet concentrates.

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