Organic Letters
Organic Letters
4 years ago

Stereoselective Total Synthesis of Carolacton

Stereoselective Total Synthesis of Carolacton
Rajib Kumar Goswami, Tapan Kumar Kuilya
A short and convergent strategy for the stereoselective total synthesis of biologically active natural product carolacton has been accomplished. Our synthesis highlights the Urpi acetal aldol, Crimmins aldol, Ireland–Claisen rearrangement, TiCl4-assisted aldol followed by β-hydroxy elimination to construct C7–C8 olefin, and ring-closing metathesis as the key steps for achieving the target molecule with an overall yield of 18.8%.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b00903

DOI: 10.1021/acs.orglett.7b00903

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.