3 years ago

Reductive Coupling of CO2, Primary Amine, and Aldehyde at Room Temperature: A Versatile Approach to Unsymmetrically N,N-Disubstituted Formamides

Reductive Coupling of CO2, Primary Amine, and Aldehyde at Room Temperature: A Versatile Approach to Unsymmetrically N,N-Disubstituted Formamides
Yanfei Zhao, Xiang Gao, Zhimin Liu, Zhengang Ke, Zhenzhen Yang, Leiduan Hao, Hongye Zhang, Yu Chen, Bo Yu
We present a simple, metal-free, and versatile route to synthesize unsymmetrically N,N-disubstituted formamides (NNFAs) from CO2, primary amine, and aldehyde promoted by an ionic liquid (1-butyl-3-methylimidazolium chloride) at room temperature. This approach features wide scopes of amines and aldehydes, and various unsymmetrical NNFAs could be obtained in good to excellent yields. The ionic liquid can be reused for at least five runs without obvious activity loss. A simple and versatile route is presented for the synthesis of unsymmetrically N,N-disubstituted formamides (NNFAs) through a three-component reductive coupling of CO2, amine, and aldehyde under mild conditions. This method affords various unsymmetric NNFAs in good to excellent yields.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201701420

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