5 years ago

Organic CO Prodrugs: Structure–CO-Release Rate Relationship Studies

Organic CO Prodrugs: Structure–CO-Release Rate Relationship Studies
Xingyue Ji, Kaili Ji, Wei Li, Vayou Chittavong, Mengyuan Zhu, Binghe Wang, Jun Zhang, Zhixiang Pan
Carbon monoxide (CO) is an endogenously produced gasotransmitter in mammals, and may have signaling roles in bacteria as well. It has many recognized therapeutic effects. A significant challenge in this field is the development of pharmaceutically acceptable forms of CO delivery with controllable and tunable release rates. Herein, the structure–release rate studies of the first class of organic CO prodrugs that release CO in aqueous solution at neutral pH is described. Structure–CO-release rate relationship studies of organic CO prodrugs reveal that CO releasing rate can be tuned by modifying the nature of the linker, substituents on dienone ring or linker, and the length of the linker.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201700936

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