Chemistry - A European Journal
Chemistry - A European Journal
5 years ago

A Highly Selective Fluorescent Probe for Detection of Hydrogen Sulfide in Living Systems: In Vitro and in Vivo Applications

A Highly Selective Fluorescent Probe for Detection of Hydrogen Sulfide in Living Systems: In Vitro and in Vivo Applications
Ripu D. Parihar, Vandana Bhalla, Shahi Imam Reja, Gurcharan Kaur, Muskan Gupta, Manoj Kumar, Puja Ohri, Neetu Sharma, Payal Bajaj
A fluorescein-based fluorescent probe has been designed and synthesised that selectively detects H2S in aqueous medium, among various analytes tested. This fluorescein-based fluorescent probe has also been successfully utilised for real-time imaging of exo- and endogenously produced H2S in cancer cells and normal cells. Moreover, the probe can also detect H2S in the rat brain hippocampus at variable depths and in living nematodes. Revealing images: A fluorescein-based fluorescent probe has been designed and synthesized to detect H2S selectively in aqueous medium containing various analytes (see figure). The probe was also successfully utilized for real-time imaging of exo- and endogenously produced H2S in cancer and normal cells. Moreover, the probe can also detect H2S in the rat brain hippocampus at variable depths and in living nematodes.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201701124

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