3 years ago

Potent mechanism-based sirtuin-2-selective inhibition by an in situ-generated occupant of the substrate-binding site, "selectivity pocket" and NAD+-binding site

Potent mechanism-based sirtuin-2-selective inhibition by an in situ-generated occupant of the substrate-binding site, "selectivity pocket" and NAD+-binding site
Maija Lahtela-Kakkonen, Taeko Kakizawa, Yukihiro Itoh, Jun Takeuchi, Natsuko Tokuda, Takayoshi Suzuki, Yuri Miura, Hiroki Tsumoto, Paolo Mellini, Miki Suzuki, Ying Li
SIRT2 is potently and selectively inhibited by in situ-generated KPM-2 (36)-ADP ribose conjugate.

Publisher URL: http://feeds.rsc.org/~r/rss/SC/~3/nk8lGcWn1wk/C7SC02738A

DOI: 2017/SC/C7SC02738A

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