Expanding the substrate scope of phenylalanine ammonia-lyase from Petroselinum crispum towards styrylalanines

5 years ago

Expanding the substrate scope of phenylalanine ammonia-lyase from Petroselinum crispum towards styrylalanines

Gergely Banoczi, Monica Ioana Tosa, Florin Dan Irimie, Alina Filip, Akos Gellert, Laszlo Poppe, Csaba Paizs, Laszlo Csaba Bencze

The substrate scope of phenylalanine ammonia-lyase from Petroselinum crispum (PcPAL) towards the L-enantiomers of racemic styrylalanines rac-1a-d were extended by reshaping the aromatic binding pocket of the active site of PcPAL by point mutations of F137.

Publisher URL: http://feeds.rsc.org/~r/rss/OB/~3/nCJsdj3SGcI/C7OB00562H

DOI: 2017/OB/C7OB00562H

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