ACS Macro Letters
ACS Macro Letters
5 years ago

Interfacial Ring-Opening Polymerization of Amino-Acid-Derived N-Thiocarboxyanhydrides Toward Well-Defined Polypeptides

Interfacial Ring-Opening Polymerization of Amino-Acid-Derived N-Thiocarboxyanhydrides Toward Well-Defined Polypeptides
Tianyi Yu, Donghui Zhang, Weiwei Xie, Brandon A. Chan, Frank R. Fronczek, David Siefker, Mirza A. Saputra, Jinbao Cao, Lu Lu
Interfacial ring-opening polymerizations (iROP) of α-amino-acid derived N-thiocarboxyanhydrides (NTAs) in hexanes or heptane suspension using soluble primary amine initiators have been demonstrated to produce polypeptides with controlled molecular weight and low-to-moderate molecular weight distribution under mild conditions. The NTA monomers were shown to have significantly enhanced moisture and thermal stability relative to N-carboxyanhydrides (NCAs), resulting in long shelf life and allowing the polymerization to occur quantitatively in open air.

Publisher URL: http://dx.doi.org/10.1021/acsmacrolett.7b00411

DOI: 10.1021/acsmacrolett.7b00411

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.