Discovery and optimization of selective inhibitors of protein arginine methyltransferase 5 by docking-based virtual screening

4 years ago

Discovery and optimization of selective inhibitors of protein arginine methyltransferase 5 by docking-based virtual screening

Jing Xing, Hong Ding, Bidong Zhang, Yulan Wang, Yu-Chih Liu, Kaixian Chen, Chenhua Zhang, Ruifeng Mao, Mingyue Zheng, Xiaomin Luo, Bing Zhou, Yaxi Yang, Cheng Luo, Yan Ye, Hualiang Jiang

A series of highly selective and potent inhibitors against PRMT5 have been achieved using virtual screening and medicinal chemistry approaches.

Publisher URL: http://feeds.rsc.org/~r/rss/OB/~3/oYGoedoCB9g/C7OB00070G

DOI: 2017/OB/C7OB00070G

You might also like

Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.