5 years ago

Enantioselective Synthesis of Spiro[indolizidine-1,3′-oxindoles]

Enantioselective Synthesis of Spiro[indolizidine-1,3′-oxindoles]
Chiara Taglienti, Joan Bosch, F. Javier Luque, Antonio Viayna, Maria Pérez, Mercedes Amat, Lucia Massi, Elies Molins, Nihan Yayik, Silvia Gazzola, Carlos Ramos
A three-step procedure for the enantioselective synthesis of spiro[indolizidine-1,3′-oxindoles], consisting of a stereoselective cyclocondensation reaction between (S)-tryptophanol and a prochiral or racemic δ-oxoester, bromination of the resulting oxazolopiperidone lactam, and a final stereoselective spirocyclization, is reported.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01818

DOI: 10.1021/acs.orglett.7b01818

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