Organic Letters
Organic Letters
5 years ago

Visible-Light-Induced Tandem Radical Addition–Cyclization of Alkenyl Aldehydes Leading to Indanones and Related Compounds

Visible-Light-Induced Tandem Radical Addition–Cyclization of Alkenyl Aldehydes Leading to Indanones and Related Compounds
Gangguo Zhu, Danyang Lu, Lichun Kong, Yimei Wan
Herein we describe a novel, visible light-induced tandem radical addition–cyclization of alkenyl aldehydes with α-bromocarbonyl compounds. A set of cyclic ketones, including indanones, cyclopentenones, 3,4-dihydronaphthalen-1(2H)-ones, and chroman-4-ones, are synthesized at room temperature with high efficiency and good functional group compatibility. It represents the first report on the catalytic 1,2-acylalkylation of unactivated alkenes.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01162

DOI: 10.1021/acs.orglett.7b01162

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