5 years ago

Metal–Organic Framework Material Inhibits Biofilm Formation of Pseudomonas aeruginosa

Metal–Organic Framework Material Inhibits Biofilm Formation of Pseudomonas aeruginosa
Alec Lutzke, Sarah M. Schweickart, Megan J. Neufeld, Bella H. Neufeld, Melissa M. Reynolds
An 85% reduction in the bacterial attachment of Pseudomonas aeruginosa is achieved using a water-stable metal–organic framework (MOF) blended with chitosan. These materials demonstrate this reduction in bacterial adhesion in the first 6 h and maintain it over the full 24 h exposure period, a remarkable impediment of biofilm formation to achieve, given the strength of this bacteria strain. The films elicit the same inhibitory effect after a second round of experiments, suggesting reusability of the materials. Characterization of the films by powder X-ray diffraction, attenuated total reflectance-IR, and scanning electron microscopy supports retention of the MOF structure within the chitosan matrix. The extensive control experiments employed in this study isolate the observed biological effects to the synthesized films, and not to possible leachates from the films. This presents the first account of using a water-stable MOF within a polymer as a means to achieve an antibacterial surface by demonstrating an 85% reduction in bacterial attachment of Pseudomonas aeruginosa. Metal–organic framework/chitosan materials are tested for inhibitory bacterial attachment using Pseudomonas aeruginosa. These materials show excellent reductions in bacterial attachment, with ≈85% reduction observed over 6 and 24 h exposure periods. The films also demonstrate reusability as an antibacterial surface. This represents the first use of a water-stable, copper-based metal–organic framework within a polymer for biofilm inhibition.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/adfm.201702255

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.