Advanced Materials
Advanced Materials
5 years ago

Multicellular Vascularized Engineered Tissues through User-Programmable Biomaterial Photodegradation

Multicellular Vascularized Engineered Tissues through User-Programmable Biomaterial Photodegradation
Christopher K. Arakawa, Cole A. DeForest, Ying Zheng, Barry A. Badeau
A photodegradable material-based approach to generate endothelialized 3D vascular networks within cell-laden hydrogel biomaterials is introduced. Exploiting multiphoton lithography, microchannel networks spanning nearly all size scales of native human vasculature are readily generated with unprecedented user-defined 4D control. Intraluminal channel architectures of synthetic vessels are fully customizable, providing new opportunities for next-generation microfluidics and directed cell function. A photodegradable material-based approach to generate endothelialized 3D vascular networks within cell-laden hydrogel biomaterials is introduced. Exploiting multiphoton lithography, microchannel networks spanning size scales of nearly all native human vasculature are readily generated with unprecedented user-defined 4D control. Intraluminal channel architectures of synthetic vessels are fully customizable, providing new opportunities for next-generation microfluidics and directed cell function.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/adma.201703156

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