5 years ago

Synthesis of (±)-Aphanorphine Using Rh-Catalyzed Cyclohydrocarbonylation

Synthesis of (±)-Aphanorphine Using Rh-Catalyzed Cyclohydrocarbonylation
Wen-Hua Chiou, Po-Chou Chen
A facile formal synthesis to aphanorphine and its analogue is described, featuring Rh-catalyzed cyclohydrocarbonylation of 2-aminodihydronaphthalene to the bridged benzazepine core. Subsequent introduction of the methyl group and functional group transformation complete the synthesis of aphanorphine and its analogue over eight steps.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b00923

DOI: 10.1021/acs.joc.7b00923

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