3 years ago

Highly Selective and Sensitive Two-Photon Fluorescence Probe for Endogenous Peroxynitrite Detection and Its Applications in Living Cells and Tissues

Highly Selective and Sensitive Two-Photon Fluorescence Probe for Endogenous Peroxynitrite Detection and Its Applications in Living Cells and Tissues
Hwan Myung Kim, Juyoung Yoon, Jun Li, Gyoungmi Kim, Chang Su Lim
A new two-photon fluorescence probe for endogenous peroxynitrite (ONOO) detection was designed and synthesized. The probe exhibits good selectivity and sensitivity for ONOO in phosphate-buffered saline solution with a low detection limit (3.5 × 10–8 M). Furthermore, the probe displays good performance in detecting endogenous ONOO, not only in RAW 264.7 cells but also in rat hippocampal tissue, with a high two-photon cross-section value (δ ≈ 100 GM) at a deep depth of 120 μm.

Publisher URL: http://dx.doi.org/10.1021/acs.analchem.7b02059

DOI: 10.1021/acs.analchem.7b02059

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