Trends in Biochemical Sciences
Trends in Biochemical Sciences
5 years ago

Inhibiting Translation One Protein at a Time

Historically, translational inhibitors have been confined to anti-bacterials that globally affect translation. Lintner et al. demonstrate that small molecules can specifically inhibit translation of a single disease-associated protein by stalling the ribosome’s nascent chain [1], opening up a new therapeutic strategy for ‘undruggable’ proteins.

Publisher URL: www.sciencedirect.com/science

DOI: S0968000417300889

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