Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters
5 years ago

Bioactive polyprenylated benzophenone derivatives from the fruits extracts of Garcinia xanthochymus

Bioactive polyprenylated benzophenone derivatives from the fruits extracts of Garcinia xanthochymus
Two new polycyclic prenylated xanthones (1 and 2) and a new phenylpropanoid glycoside (3), along with seven known compounds (4–10) were isolated from the fruits of Garcinia xanthochymus. The structures were elucidated by 1D- and 2D-NMR, and HRMS experiments. The isolates were evaluated for their inhibitory effects against the viability of U251MG glioblastoma and MDA-MB-231 breast cancer cells that harbor an aberrantly active signal transducer and exhibit activation of transcription 3 (STAT3), and compared to normal NIH3T3 mouse fibroblasts. Among the isolates, compounds 1, 2, 5, and 6–9 inhibited the viability of glioma cancer cells with IC50 values in the range of 1.6–6.5μM. Furthermore, treatment of U251MG with 6 and 7 inhibited intracellular STAT3 tyrosine phosphorylation and glioma cell migration in vitro, respectively.

Publisher URL: www.sciencedirect.com/science

DOI: S0960894X17306844

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