3 years ago

Flavonoid glycosides from Barringtonia acutangula

Flavonoid glycosides from Barringtonia acutangula
Using various chromatographic separation techniques, ten flavonoid glycosides, including six new compounds namely barringosides A−F (16), were isolated from a methanol extract of the Barringtonia acutangula leaves. The structure elucidation was confirmed by spectroscopic analyses, including 1D and 2D NMR, and HR ESI MS. Their inhibitory effects on LPS-induced NO production in RAW264.7 cells were also evaluated. Among the isolated compounds, quercetin 3-O-β-d-(6-p-hydroxybenzoyl)galactopyranoside (9) showed significant effect with an IC50 of 20.00±1.68µM. This is the first report of these flavonoid glycosides from Barringtonia genus and their inhibition on LPS-induced NO production in RAW264.7 cells was reported here for the first time.

Publisher URL: www.sciencedirect.com/science

DOI: S0960894X17306704

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