Organic Letters
Organic Letters
5 years ago

Tandem Hydroalumination/Cu-Catalyzed Asymmetric Vinyl Metalation as a New Access to Enantioenriched Vinylcyclopropane Derivatives

Tandem Hydroalumination/Cu-Catalyzed Asymmetric Vinyl Metalation as a New Access to Enantioenriched Vinylcyclopropane Derivatives
Ilan Marek, Sema Akyol, Veronika Werner, Daniel S. Müller, Hans-Günther Schmalz
Herein, we report the first enantio- and diastereoselective addition of stereodefined vinyl organometallic reagents to cyclopropenes. The operationally simple tandem hydroalumination and copper-catalyzed vinylmetalation allows for the unique access of a diverse set of enantioenriched vinylcyclopropane derivatives.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01661

DOI: 10.1021/acs.orglett.7b01661

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