3 years ago

Enantioselective Spirocyclopropanation of para-Quinone Methides Using Ammonium Ylides

Enantioselective Spirocyclopropanation of para-Quinone Methides Using Ammonium Ylides
Lukas Roiser, Mario Waser
The use of Cinchona alkaloid-based chiral ammonium ylides allows for the first highly enantioselective and broadly applicable spirocyclopropanation reactions of para-quinone methides. This strategy provides a straightforward protocol toward the chiral spiro[2.5]octa-4,7-dien-6-one skeleton, which is a frequently found structural motif in important biologically active molecules.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b00869

DOI: 10.1021/acs.orglett.7b00869

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