Journal of Organic Chemistry
Journal of Organic Chemistry
5 years ago

Metal-Free Three-Component Regioselective Aminofluorination of Styrene Derivatives

Metal-Free Three-Component Regioselective Aminofluorination of Styrene Derivatives
Qian Zhang, Qiao Zhang, Guangfan Zheng, Yan Li
The first metal-free, three-component radical aminofluorination of styrene derivatives has been developed, which employs Selectfluor as a fluorine source and azole derivatives as a nitrogen source. This transformation proceeds with high regioselectivity, providing various 1,2-aminofluorination compounds under mild conditions. Mechanistic studies suggest that the aminofluorination process might involve radical fluorination followed by nucleophilic amination.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b01089

DOI: 10.1021/acs.joc.7b01089

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