Inorganic Chemistry
Inorganic Chemistry
5 years ago

Gallium Complexation, Stability, and Bioconjugation of 1,4,7-Triazacyclononane Derived Chelators with Azaheterocyclic Arms

Gallium Complexation, Stability, and Bioconjugation of 1,4,7-Triazacyclononane Derived Chelators with Azaheterocyclic Arms
Mark D. Bartholomä, Manfred Keller, Alexander Schmidtke, Lorenz Bier-Schorr, Tilman Läppchen, Jason P. Holland, Christian Weinmann, Yvonne Kiefer
We recently demonstrated the applicability of 1,4,7-triazacyclononane derived ligands with up to three azaheterocyclic arms as chelating agents for 64Cu used in positron emission tomography (PET). Here, we describe their complex formation with the PET isotope 68Ga3+. These ligands form rigid 1:1 chelates with natGa3+ in solution. In 68Ga3+ complexes of the five-coordinate bifunctional chelator NODIA-Me, the remaining coordination site of the octahedron is occupied by monodentate ligands such as chloride or hydroxide.

Publisher URL: http://dx.doi.org/10.1021/acs.inorgchem.7b01129

DOI: 10.1021/acs.inorgchem.7b01129

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.