Ischemic and hypoxic conditioning: Potential for protection of vital organs
Abstract
New Findings
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What is the topic of this review?
Paradoxically, ischemic and hypoxic conditioning paradigms protect vital organs from ischemic and hypoxic injury. In this Symposium Report, we focus on remote ischemic preconditioning (RIPC) and hypoxic preconditioning as novel therapeutic approaches for cardiac‐ and neuro‐protection.
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What advances does it highlight?
Growing interest in ischemic and hypoxic preconditioning has facilitated improved understanding of associated mechanisms and signaling pathways, and identified potential pitfalls with application of these therapies to clinical trials. Novel adaptations of preconditioning paradigms have also been developed, including intermittent hypoxia training, RIPC training, and RIPC‐exercise, extending their utility to chronic settings.
Publisher URL: https://physoc.onlinelibrary.wiley.com/doi/abs/10.1113/EP087122
DOI: 10.1113/EP087122
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