3 years ago

Alkyne Hydroheteroarylation: Enantioselective Coupling of Indoles and Alkynes via Rh-Hydride Catalysis

Alkyne Hydroheteroarylation: Enantioselective Coupling of Indoles and Alkynes via Rh-Hydride Catalysis
Vy M. Dong, Yamin Zhu, Quentin D. Tercenio, Faben A. Cruz, Zengming Shen
We report an enantioselective coupling between alkynes and indoles. A Rh-hydride catalyst isomerizes alkynes to generate a metal-allyl species that can be trapped with both aromatic and heteroaromatic nucleophiles.

Publisher URL: http://dx.doi.org/10.1021/jacs.7b05893

DOI: 10.1021/jacs.7b05893

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