3 years ago

Divergent Synthesis of Polycyclic Indolines: Copper-Catalyzed Cascade Reactions of Propargylic Carbamates and Indoles

Divergent Synthesis of Polycyclic Indolines: Copper-Catalyzed Cascade Reactions of Propargylic Carbamates and Indoles
Ya-Ni Wang, Liang-Qiu Lu, Wen-Jing Xiao, Bao-Cheng Wang, Tian-Ren Li
Polycyclic indolines are the common and core structural motif of many indole alkaloids that usually exhibit biological activities. Here, we describe two copper-catalyzed cascade reactions between propargylic carbamates and indoles. By doing so, one-step and divergent synthesis of structurally distinct polycyclic indolines, quinoline-fused indolines, C(3a)-indolyl furoindolines, and pyrroloindolines was achieved in high synthetic efficiency and selectivity.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01903

DOI: 10.1021/acs.orglett.7b01903

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