Polymer
Polymer
5 years ago

Why does TMAO stabilize the globule state of PNIPAM?

Why does TMAO stabilize the globule state of PNIPAM?
Experimental measurements have shown that trimethylamine N-oxide, TMAO, is able to stabilize the globule state of PNIPAM [Phys.Chem.Chem.Phys. 2016; 18:31459], the same effect it has towards the native state of globular proteins. The TMAO stabilizing action is rationalized by means of the same theoretical approach used to address the entropic driving force and the effect of sodium salts, urea and tetramethylurea on PNIPAM collapse [Phys.Chem.Chem.Phys. 2015; 17:27750; Phys.Chem.Chem.Phys. 2016; 18:14426]. TMAO stabilizes the PNIPAM globule state because its addition to water causes an increase in the magnitude of the solvent-excluded volume effect, and only a small increase in the magnitude of the PNIPAM-solvent energetic attractions, since TMAO interacts preferentially with water.

Publisher URL: www.sciencedirect.com/science

DOI: S0032386117307188

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.