5 years ago

Comparative analysis of PVA hydrogels incorporating two natural antimicrobials: Punica granatum and Arnica montana tinctures

Comparative analysis of PVA hydrogels incorporating two natural antimicrobials: Punica granatum and Arnica montana tinctures
Renata Nunes Oliveira, Rossana Mara da Silva Moreira Thiré, Caio Marcio Paranhos da Silva, Ana Paula Duarte Moreira, Garrett Brian McGuinness, Roberta Helena Mendonça
Poly(vinyl alcohol) (PVA) hydrogels are biocompatible materials that retain relatively high amounts of aqueous fluids in their network. The incorporation of antimicrobial natural products, such as pomegranate and arnica, is a strategy for coupling their bactericidal effects with the favorable properties of the gels for wound healing treatment. The goal of this work was to investigate the microstructural, mechanical, and release properties of PVA–pomegranate and PVA-arnica samples. Physical interactions were observed by Fourier transform infrared spectra in PVA–pomegranate samples. The addition of pomegranate to PVA led to high Tg, probably related to the physical interactions, and low Tm and Xc, possibly due to the pomegranate location between PVA chains. Increased levels of arnica were associated with a slight decrease in samples' Xc, probably due to a physical barrier imposed by arnica to the interaction of PVA chains. PVA samples presented higher swelling than the samples containing natural products. High amounts of pomegranate in the samples led to high weight loss and high phenols and flavonoids delivery. Arnica release seemed to be more difficult than the pomegranate release. All samples presented relative high mechanical properties. In addition, pomegranate samples present higher potential to deliver active compounds than arnica samples. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45392.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/app.45392

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