Chemistry - A European Journal
Chemistry - A European Journal
5 years ago

Frontispiece: Sulfur–Fluoride Exchange (SuFEx)-Mediated Synthesis of Sterically Hindered and Electron-Deficient Secondary and Tertiary Amides via Acyl Fluoride Intermediates

Frontispiece: Sulfur–Fluoride Exchange (SuFEx)-Mediated Synthesis of Sterically Hindered and Electron-Deficient Secondary and Tertiary Amides via Acyl Fluoride Intermediates
Marie-Claire Giel, John E. Moses, Christopher J. Smedley, Christian Spiteri, Andrew S. Barrow, Pallavi Sharma
The development of “SuFExAmide”: A new sulfur–fluoride exchange (SuFEx) click chemistry based protocol for the efficient amidation of carboxylic acids via acyl fluoride intermediates is described. Benzene-1,3-disulfonyl fluoride has been synthesized as a cost effective, powerful and versatile coupling agent, which delivers challenging secondary and tertiary amides in excellent yields from sterically hindered and electron-deficient amines. For more details, see the Communication by J. E. Moses et al on page 9990 ff.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201784262

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