5 years ago

Cobalt-Catalyzed Esterification of Amides

Cobalt-Catalyzed Esterification of Amides
Grégory Danoun, Corinne Gosmini, Yann Bourne-Branchu
The first cobalt-catalyzed amide activation of N-Boc-amides, and their conversion into esters, is reported here. This new methodology presents a very practical process that does not require an inert atmosphere, uses an inexpensive cobalt catalyst, and proceeds under mild reaction conditions. This catalytic system has a broad substrate scope and has been shown to be highly efficient, with catalyst loadings as low as 1 mol %. Of gentler, milder mold: A practical mild and efficient cobalt-catalytic system is described that converts amides into esters. This methodology is complementary to previous nickel-catalyzed systems, affording new selectivity and a more diverse range of amide substrates, including common C−H bond activation directing groups. This new reaction requires neither inert atmosphere nor distilled solvents and even proceeds at low catalyst loading such as 1 mol % catalyst.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201702608

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