4 years ago

An Approach to 3-(Indol-2-yl)succinimide Derivatives by Manganese-Catalyzed C–H Activation

An Approach to 3-(Indol-2-yl)succinimide Derivatives by Manganese-Catalyzed C–H Activation
Jun-Fang Gong, Guang-Chao Yang, Yang Li, Xue-Hong Li, Jun-Ru Guo, Shuang-Liang Liu, Mao-Ping Song
The manganese-catalyzed addition of C-2 position of indoles to maleimides has been achieved under additive-free conditions. The manganese catalyst exhibits excellent chemo- and regioselectivity, good functional group compatibility, and high catalytic efficiency. The substrate scope can also be extended to maleates, ethyl acrylate, 1,4-dihydro-1,4-epoxynaphthalene, pyrroles, and 2-phenylpyridine, which further demonstrates the universality of this straightforward approach.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01795

DOI: 10.1021/acs.orglett.7b01795

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