3 years ago

Insight into the Role of Additives in Controlling Polymorphic Outcome: A CO2-Antisolvent Crystallization Process of Carbamazepine

Insight into the Role of Additives in Controlling Polymorphic Outcome: A CO2-Antisolvent Crystallization Process of Carbamazepine
Luis Padrela, Kevin M. Ryan, Jacek Zeglinski
This work explores the mechanisms underlying the influence of selected additives in the crystallization of distinct polymorphic forms of carbamazepine (CBZ) using a gas antisolvent process. The type of additive used in the CO2-antisolvent crystallization process impacted both the product crystal polymorphic form and size. A detailed molecular-level analysis along with high-level density functional theory calculations provides a mechanistic insight into the surfactant-templated nucleation of CBZ polymorph II.

Publisher URL: http://dx.doi.org/10.1021/acs.cgd.7b00163

DOI: 10.1021/acs.cgd.7b00163

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