Organic Letters
Organic Letters
5 years ago

Acetic Acid Promoted Redox Annulations with Dual C–H Functionalization

Acetic Acid Promoted Redox Annulations with Dual C–H Functionalization
Zhengbo Zhu, Daniel Seidel
Amines such as 1,2,3,4-tetrahydroisoquinoline undergo redox-neutral annulations with 2-alkylquinoline-3-carbaldehydes as well as the corresponding 4-alkyl isomers and pyridine analogues. These processes involve dual C–H bond functionalization. Acetic acid is used as a cosolvent and acts as the sole promoter of these transformations.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01047

DOI: 10.1021/acs.orglett.7b01047

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