Tetrahedron
Tetrahedron
5 years ago

Novel quinoxaline derivative: Solubilization by surfactant solutions and membranotropic properties

Novel quinoxaline derivative: Solubilization by surfactant solutions and membranotropic properties
Novel compound, (E)-3-([1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-on-1-yl)acrylic acid, containing triazole and quinoxaline moieties has been synthesized and characterized. The solubility of the compound in water and surfactant solutions has been estimated at different pH. It has been shown that the increase in solubility is due to hydrophobic effect as well as electrostatic interactions. The capability of this compound to integrate within dipalmitoylphosphocholine lipid bilayer has been evaluated. An increase in membranotropic properties after encapsulation of this compound in nanocontainers based on dicationic surfactant has been exhibited.

Publisher URL: www.sciencedirect.com/science

DOI: S0040402017307196

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