3 years ago

Pregnancy in Acromegaly is safe and is associated with improvements in GH/IGF-1 concentrations.

Anne Marie Hannon, Triona O'Shea, Claire Thompson, Mark J Hannon, Rosemary Dineen, Aftab Khalid Khattak, James Gibney, Domhnall O'Halloran, Steve Hunter, Chris J Thompson, Mark Sherlock
Pregnancy is rarely reported in acromegaly. Many patients are diagnosed in later life and younger patients may have subfertility due to hypopituitarism. We present a case series of 17 pregnancies in 12 women with acromegaly. 12 women with acromegaly who completed pregnancy were identified from centres involved in the Irish Pituitary Study. 11 women had pituitary macroadenomas, one woman had a microadenoma. Only 5/17 pregnancies had optimal biochemical control of acromegaly pre-conception, as defined by IGF-1 concentration in the age related reference level and plasma GH concentration of <2ug/L. In 6/17 pregnancies, dopamine agonist treatment was continued during pregnancy; all other acromegaly treatments were discontinued during pregnancy. Effect of pregnancy on acromegaly; No patient developed new visual field abnormalities, or symptoms suggestive of tumour expansion during pregnancy. In 9/12 patients, plasma IGF-1 concentrations that were elevated pre-conception normalized during pregnancy. There was a reduction in plasma IGF-1 concentrations, though not into the normal range, in a further 2 pregnancies. Effect of acromegaly on pregnancy; 15 healthy babies were born at term; one patient underwent emergency C-section at 32 weeks, for pre-eclampsia and one twin pregnancy had an elective caesarean section at 35 week's gestation. Blood pressure remained within normal limits in the remainder of the pregnancies. Gestational diabetes did not develop in any pregnancy. Our data suggests that pregnancy in women with acromegaly is generally safe, from a maternal and foetal perspective. Furthermore, biochemical control tends to improve despite the withdrawal of somatostatin analogue therapy during pregnancy.

Publisher URL: http://doi.org/10.1530/EJE-18-0688

DOI: 10.1530/EJE-18-0688

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.