3 years ago

Prediction of fetal blood group and platelet antigens from maternal plasma using next‐generation sequencing

Orzińska Agnieszka, Guz Katarzyna, Mikula Michal, Kluska Anna, Balabas Aneta, Ostrowski Jerzy, Uhrynowska Małgorzata, Kopeć Izabella, Dębska Marzena, Luterek Katarzyna, Brojer Ewa

Abstract

BACKGROUND

Fetuses whose mothers have produced antibodies to red blood cell (RBC) or platelet antigens are at risk of being affected by hemolytic disease or alloimmune thrombocytopenia, respectively, only if they inherit the incompatible antigen. Noninvasive diagnosis of the fetal antigen is employed for management of immunized pregnancies, but the specific detection of SNPs, encoding the majority of antigens, in maternal plasma is still a challenge. We applied targeted next‐generation sequencing (NGS) to predict the fetal antigen based on the detection of fetomaternal chimerism.

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