3 years ago

The long non‐coding RNA LINC00941 and SPRR5 are novel regulators of human epidermal homeostasis

Christian Ziegler, Johannes Graf, Stefan Faderl, Jessica Schedlbauer, Nicholas Strieder, Bianca Förstl, Rainer Spang, Astrid Bruckmann, Rainer Merkl, Sonja Hombach, Markus Kretz

Abstract

Several long non‐coding RNAs (lncRNAs) act as regulators of cellular homeostasis; however, few of these molecules were functionally characterized in a mature human tissue environment. Here, we report that the lncRNA LINC00941 is a crucial regulator of human epidermal homeostasis. LINC00941 is enriched in progenitor keratinocytes and acts as a repressor of keratinocyte differentiation. Furthermore, LINC00941 represses SPRR5, a previously uncharacterized molecule, which functions as an essential positive regulator of keratinocyte differentiation. Interestingly, 54.8% of genes repressed in SPRR5‐deficient epidermal tissue are induced in LINC00941‐depleted organotypic epidermis, suggesting a common mode of action for both molecules.

Publisher URL: https://onlinelibrary.wiley.com/doi/abs/10.15252/embr.201846612

DOI: 10.15252/embr.201846612

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