3 years ago

A phase 1 trial of SGN‐CD70A in patients with CD70‐positive, metastatic renal cell carcinoma

Sumanta K. Pal, Andres Forero-Torres, John A. Thompson, John C. Morris, Saurabh Chhabra, Christopher J. Hoimes, Nicholas J. Vogelzang, Thomas Boyd, Paulo G. Bergerot, Jacob J. Adashek, Hong Li, Xuesong Yu, Elaina M. Gartner, Anne-Sophie Carret, David C. Smith

Abstract

Background

Cluster of differentiation 70 (CD70) is frequently expressed in renal cell carcinoma (RCC) and has immunomodulatory properties. An antibody‐drug conjugate targeting CD70, SGN‐CD70A, was developed to treat patients with CD70‐positive RCC.

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