3 years ago

# The cTnT response to acute exercise at the onset of an endurance training program: evidence of exercise preconditioning?

Haifeng Zhang, Jinlei Nie, Zhaowei Kong, Wenling Cao, Xiangui Zhu, Ziwei Zheng, Keith George

### Purpose

Exercise induces a cardioprotective effect referred to as “preconditioning”. Whether the preconditioning impacts upon the cardiac troponin T (cTnT) response to subsequent exercise bouts is unclear. This study investigated the effects of an initial exercise bout, a second exercise bout 48 h later, as well as subsequent exercise every 48 h for 4 days or a single identical exercise bout after 8 days of inactivity gap on cTnT response to acute exercise.

### Methods

Twenty-eight sedentary overweight young women were randomly assigned to either six bouts of exercise each separated by 48 h or three bouts of exercise with 48 h between the first two bouts and 8 days between the second and third bouts. All exercise bouts were identical (60% $$\dot {V}{{\text{O}}_{2{\rm max} }}$$ , 200 kJ) and the total testing period (10 days) was the same for both groups. cTnT was assessed before and after the 1st, 2nd, and final exercise bouts.

### Results

cTnT increased (129%, P < 0.05) after the first bout of exercise in both groups (peak post-exercise cTnT, median [range], ng l−1: 3.43[< 3.00−27.26]) with no between-group differences in the response. The second exercise bout had no significant (P > 0.05) effect on post-exercise cTnT (< 3.00[< 3.00−21.96]). The final exercise bout resulted in an increase (190%, P < 0.05) in cTnT (4.35[< 3.00−13.05]) in both groups.

### Conclusions

A single bout exercise resulted in a temporary blunting of cTnT response to acute exercise 48 h later. The effect of exercise preconditioning was not preserved, regardless of whether followed by repeated exercise every 48 h or a cessation of exercise for 8 days.

DOI: 10.1007/s00421-019-04074-0

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